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Human PTP1B Protein, His tag

Tyrosine-protein phosphatase non-receptor type 1,Protein-tyrosine phosphatase 1B (PTP-1B),PTPN1

价格 ￥1,400.00 （ 1-2周）
货号 S0A0168
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B (PTP-1B), PTPN1

  • Accession

    P18031

  • 表达序列

    Protein sequence (P18031, Met1-Asp298, with C-His tag) MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED

  • 表达宿主

    E.coli

  • 分子量

    Predicted MW: 36.4 kDa Observed MW: 35 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Protein - tyrosine phosphatase 1B (PTP1B) is a crucial enzyme belonging to the protein tyrosine phosphatase family. PTP1B is widely distributed in various tissues such as adipose, liver, muscle, and epithelial cells, mainly located in the endoplasmic reticulum of the cytoplasm. It specifically hydrolyzes the phosphate group on the phosphorylated tyrosine residue, maintaining the balance of tyrosine protein phosphorylation with protein tyrosine kinases and participating in cell signal transduction. PTP1B negatively regulates the insulin and leptin signaling pathways, and its over - expression is closely related to the occurrence of type 2 diabetes, obesity, and other diseases.

  • 电泳

    • 2μg（R: reducing conditions）

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