Mouse Rig-I/DDX58 Protein, hFc tag
Antiviral innate immune response receptor RIG-I,ATP-dependent RNA helicase DDX58,DEAD box protein 58,RIG-I-like receptor 1 (RLR-1),RNA sensor RIG-I,Retinoic acid-inducible gene 1 protein (RIG-1),Retinoic acid-inducible gene I protein (RIG-I),Rigi,Ddx58
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物种
Mouse分子别名
Antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1 (RLR-1), RNA sensor RIG-I, Retinoic acid-inducible gene 1 protein (RIG-1), Retinoic acid-inducible gene I protein (RIG-I), Rigi, Ddx58Accession
Q6Q899表达序列
Protein sequence (Q6Q899, Ser240-Leu450, with C-hFc tag) SPLKPRNYQLELALPAKKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGYNIASISGATSDSVSVQHIIEDNDIIILTPQILVNNLNNGAIPSLSVFTLMIFDECHNTSKNHPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAALDASVIATVRDNVAEL
表达宿主
HEK293分子量
Predicted MW: 49.2 kDa Observed MW: 56 kDa纯度
＞90% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
with C-hFc tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
RIG-I (retinoic acid-inducible gene I) is a cytosolic pattern recognition receptor (PRR) that can mediate induction of a type-I interferon (IFN1) response. RIG-I is an essential molecule in the innate immune system for recognizing cells that have been infected with a virus. These viruses can include West Nile virus, Japanese Encephalitis virus, influenza A, Sendai virus, flavivirus, and coronaviruses. RIG-I is an ATP-dependent DExD/H box RNA helicase that is activated by immunostimulatory RNAs from viruses as well as RNAs of other origins. RIG-I recognizes short double-stranded RNA (dsRNA) in the cytosol with a 5' tri- or di-phosphate end or a 5' 7-methyl guanosine (m7G) cap (cap-0), but not RNA with a 5' m7G cap having a ribose 2′-O-methyl modification (cap-1).
电泳
2μg（R: reducing conditions）
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