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Human RAGE Protein, His tag

Advanced glycosylation end product-specific receptor,Receptor for advanced glycosylation end products,AGER

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0134
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER

  • Accession

    Q15109

  • 表达序列

    Protein sequence (Q15109, Ala23-Glu322, with C-His tag) AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIE

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 34 kDa Observed MW: 50 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • RAGE (receptor for advanced glycation end products), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family. Its name comes from its ability to bind advanced glycation end products (AGE), which include chiefly glycoproteins, the glycans of which have been modified non-enzymatically through the Maillard reaction. In view of its inflammatory function in innate immunity and its ability to detect a class of ligands through a common structural motif, RAGE is often referred to as a pattern recognition receptor. RAGE also has at least one other agonistic ligand: high mobility group protein B1 (HMGB1). The interaction between RAGE and its ligands is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesized to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors.

  • 生物活性

    • Immobilized Human HMGB1 at 4 μg/mL (50 μL/well) can bind Human RAGE Protein, His tag with EC50 of 0.21-0.25 μg/mL.

  • 电泳

    • 2μg（R: reducing conditions）

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