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Human IgG4 Fc protein

Immunoglobulin heavy constant gamma 4,Ig gamma-4 chain C region,IGHG4

价格 ￥800.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0110
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Immunoglobulin heavy constant gamma 4, Ig gamma-4 chain C region, IGHG4

  • Accession

    P01861

  • 表达序列

    Protein sequence (P01861, Glu99-Gly326) ESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 25.6 kDa；Observed MW: 30 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Each IgG antibody has two paratopes. Antibodies are major components of humoral immunity. IgG is the main type of antibody found in blood and extracellular fluid, allowing it to control infection of body tissues. By binding many kinds of pathogens such as viruses, bacteria, and fungi, IgG protects the body from infection. There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum. Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene. If antigen persists, high affinity IgG4 is produced, which dampens down inflammation by helping to curtail FcR-mediated processes.

  • 生物活性

    • Immobilized Human IgG4 Fc protein at 4 μg/mL (50 μL/well) can bind Staphylococcus aureus Protein A(B), His tag (Cat. No. S0A0109) with EC50 of 5.312-5.768 ng/ml.

    • Immobilized Human IgG4 Fc protein at 10 μg/mL (50 μL/well) can bind Human Fc γ RIa/CD64, His tag (Cat. No. S0A1105) with EC50 of 12.72-13.34 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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