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物种
Human分子别名
Interferon-induced protein p78 (IFI-78K), Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1Accession
P20591表达序列
Protein sequence (P20591, Ala37-Glu366, with C-10*His) AENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEGGGGSHHHHHHHHHH
表达宿主
E.coli分子量
Predicted MW: 38.4 kDa Observed MW: 43 kDa纯度
＞90% by SDS-PAGE内毒素含量
<1EU/μg标签
with C-10*His性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases. MX1 is an antiviral protein that confers resistance to RNA viruses. MX1 has GTPase activity, and GTP-bound MX1 adopts a conformation that enables interaction with viral nucleocapsids. This interaction blocks transport of viral nucleocapsids to the nucleus, which prevents transcription of the viral genome. Structural studies suggest that the antiviral activity of MX1 involves the formation of MX1 oligomeric rings around viral nucleocapsids. In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection.
电泳
2 μg（R: reducing conditions）
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