分享产品介绍 评论(0)
物种
Human分子别名
Angiopoietin-5 (ANG-5), ANGPT5Accession
Q9Y5C1表达宿主
HEK293分子量
Theoretical:25.4 kDa Actual:28-35 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/mg标签
with C-10*His性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.储存条件
12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.
ANGPTL3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), thereby increasing plasma triglyceride, LDL cholesterol and HDL cholesterol in mice and humans. In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.
生物活性
Immobilized Human ANGPTL3, His tag at 4 μg/mL (50 μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 1.329-1.869 ng/ml.
电泳
2μg（R: reducing conditions）
评论(0)