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物种
Mouse分子别名
Granzyme B, CTLA-1, Cytotoxic cell protease 1 (CCP1), Fragmentin-2Accession
P04187表达序列
Protein sequence(P04187, Lys17-Ser247, with C-10*His) KAGEIIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSSGGGGSHHHHHHHHHH
表达宿主
HEK293分子量
Theoretical:27.4kDa Actual:31kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标签
His Tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.
Granzyme B (GZMB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells.Granzyme B has also been found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells. The secondary functions of granzyme B are also numerous. Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling.
电泳(SDS-PAGE)
![item.picture[0].fileOrgName](https://univ-sdt.oss-cn-shanghai.aliyuncs.com/prod/202302/18ce022636974e26999307deba898911.jpg)
2μg (R: reducing conditions)
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