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物种
Human分子别名
PLGFAccession
P49763-2表达序列
Protein sequence (P49763-2, Leu19-Arg149, with C-His Tag) LPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRPLREKMKPERCGDAVPRR
表达宿主
HEK293分子量
Predicted MW: 16.4 kDa Observed MW: 30 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Placental Growth Factor (PIGF) is a key angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family. It is primarily produced by the placenta and is crucial for normal placental vascular development during pregnancy. Unlike VEGF-A, PIGF specifically binds to the VEGFR-1 receptor, modulating vascular growth and inflammation. Its levels are typically low in healthy adults but significantly elevated in pre-eclampsia, a serious pregnancy complication, making it a critical diagnostic biomarker. Beyond obstetrics, PIGF is implicated in pathological angiogenesis, such as in cancer and ischemic diseases, where it promotes blood vessel growth, positioning it as a potential therapeutic target in these conditions.
生物活性
Immobilized Human PIGF Protein, His Tag at 10 μg/mL (100 μL/well) can bind Recombinant Human VEGFR1 (C-Fc) with EC50 of 15.9-18.4 ng/ ml.
电泳
2μg（R: reducing conditions）
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