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物种
Human分子别名
Metastatic lymph node gene 19 protein (MLN19)、Proto-oncogene Neu、Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2表达序列
QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTGGGGSHHHHHHHHHH
表达宿主
HEK293分子量
95kDa纯度
＞95% by SDS-PAGE
标记
Unconjugated标签
His Tag性状
Lyophilized Powder溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 ℃to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.
Erbb2 is a member of the human epidermal growth factor receptor family. Amplification or over-expression of Erbb2 has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. It is strongly associated with increased disease recurrence and a poor prognosis. Over-expression of Erbb2 is also known to occur in ovarian, stomach, adenocarcinoma of the lung and aggressive forms of uterine cancer. Due to its critical role in cancer development and progression, Erbb2 is the target of the monoclonal antibody trastuzumab.
生物活性
Immobilized Human Erbb2, His Tag at 2 μg/mL (50 μL/well) can bind Anti-Human HER2(Pertuzumab) Monoclonal Antibody with EC50 of 24.98-28.27 ng/ ml.
电泳
- 2μg（R: reducing conditions）
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