肿瘤研究

肿瘤研究概述

斯达特生物提供肿瘤药物研发全流程解决方案，依托公司在单B细胞抗体开发、重组蛋白表达、抗体工程与多平台验证体系的核心优势，覆盖从肿瘤靶抗原设计、荷瘤及免疫动物模型筛选、先导分子工程化改造到体内外药效学及安全性验证的全链条服务。我们专注于肿瘤免疫治疗与靶向治疗两大方向，针对免疫检查点（如PD-1/PD-L1）、肿瘤相关抗原（TAA）及肿瘤微环境（TME）调节分子，高效支持单抗、双抗、ADC（抗体药物偶联）及CAR-T候选药物开发。斯达特生物致力于为全球药企及科研机构提供高特异性、高亲和力、具备良好成药性的抗体工具与定制化解决方案，加速下一代抗肿瘤药物的发现与临床前研究进程。

立即咨询

相关文献

A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma

杂志名称： Biomaterials

作者： Hao Tian; Hongpei Deng; Xinlong Liu; Chang Liu; Chuan Zhang; Kam W. Leong; Jing Ruan; Xianqun Fan

IF: 12.8

Peripheral nerve injury-induced remodeling of the tumor-associated macrophages promotes immune evasion in breast cancer

杂志名称： Journal of Experimental & Clinical Cancer Research

作者： Y Jiang, W Zeng, Y Feng, X Deng, J Wang

IF: 11.4

Ascorbic Acid-Derived Supramolecular Gels Induce Immunogenic Ferroptosis in Cancer Cells to Potentiate Tumor Immunotherapy

杂志名称： ACS Nano

作者： Wenjiao Cai,Yuelan Sun,Wenyue Xu, Xiuru Kuang,Zhe Zhang, Xiang Cao, Junyu Xu, Yi Li, Yongzhuo Huang,Shiyang Shen

IF: 16.1

A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy

杂志名称： Nature Chemical Biolog

作者： Jia-Luo Huang, Lei-Ming Wu, Shu-Qi Wu, Fang-Yu Yuan, Han-Zhuang Weng, Dong Huang, Lu Gan, Shuo-Bin Chen, Gui-Hua Tang & Sheng Yin

IF: 13.7

MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer

杂志名称： Acta Pharmacol Sin

作者： J Peng, M Shao, Y Li, J Feng, X Zhang, C Xu

IF: 8.4

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor-Intrinsic PD-1/c-MET Signaling in Pancreatic Cancer

杂志名称： Advanced Science

作者： Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu

IF: 14.1

Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

杂志名称： Adv Sci (Weinh)

作者： Guo K, Yang L, Huang Z, Qian K, Shi Y, Fei M, Feng Y, Chen Z, Qiu M, Tang L, Li A, Lv Z, Liu J, Chen Z, Dong K, Wang Z.

IF: 14.1

Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis

杂志名称： Cancer Immunol Res

作者： L Xu, X Zhang, X Lai, H Chen, S Liao… - Cancer Immunology …, 2025 - aacrjournals.org

IF: 8.2

Microneedle Patch-Aided Intratumor Co-Delivery of FOLFIRINOX, Surufatinib and αPD-1 for Synergistic Efficacy of Combined Chemo-and Immuno-Therapy of PDAC

杂志名称： Materials Today

作者： T Kong, X Xu, C Wu, Z Qiu, BY Hu, Z Qi, H Dong

IF: 21.1