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IL-28A/IFN-λ2 Protein, Mouse

Interferon lambda-2,IFN-lambda-2,Interleukin-28A,IL-28A

价格 ￥2,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040330
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Interferon lambda-2; IFN-lambda-2; Interleukin-28A; IL-28A;

  • Accession

    Q4VK74

  • 表达序列

    Asp20-Val193

  • 表达宿主

    E.coli

  • 分子量

    20 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Test in progress.

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 150mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nat Immunol. 2003 Jan;4(1):63-8.

背景介绍

  • Interferon lambda 2 (IFN-λ2), also known as IL-28A, is a member of the type III interferon family, which also includes IFN-λ1 and IFN-λ3. IFN-λ2 plays a crucial role in the innate immune response to viral infections and has been shown to exhibit antiviral activity against a variety of viruses, including hepatitis C virus, influenza virus, and others. It signals through the IFN-λ receptor complex, leading to the activation of JAK-STAT signaling pathways and the induction of interferon-stimulated genes (ISGs) that contribute to the antiviral defense mechanisms. IFN-λ2 is primarily produced by immune cells, such as dendritic cells and macrophages, in response to viral stimuli and functions as a key mediator of the host's defense against viral pathogens.

  • 生物活性

    • Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is 2.1-2.9 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

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