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IL-31 Protein, Canine

IL-31,IL31,Interleukin-31

价格 ￥1,690.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040130
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Canine

  • 分子别名

    IL-31,IL31,Interleukin-31

  • Accession

    C7G0W1

  • 表达序列

    Ser24-Gln159 with C terminal 8*His

    MSHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQHHHHHHHH

  • 表达宿主

    E.coli

  • 分子量

    17kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized powder

  • 缓冲体系

    PBS, pH7.4, 5% Trehalose.

  • 溶解方法

    econstitute at 0.1-0.5mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. J Allergy Clin Immunol. 2023 Jul 13;S0091-6749(23)00888-6. Online ahead of print.
    2. Allergy. 2023 Jul 13. Online ahead of print.
    3. Clin Exp Med. 2023 Jul 1. Online ahead of print.

  • 稀释度

背景介绍

  • IL-31 which produced by activated Th2-type T cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.

  • 生物活性

    • Dose-dependent changes in STAT3 phosphorylation by DH-82 cells in response to Recombinant Canine IL-31 His,The EC50 for this effect is 80- 200ng/mL in the presence of 20ng/mL Recombinant Canine IFN-γ.

  • 电泳

    • 1μg ( R: reducing condition, N: non-reducing condition).


  • ELISA

    • Measured by its binding ability in a functional ELISA. When Recombinant Canine IL-31 His Tag is immobilized 2.5µg/mL (100µL/well), Recombinant Canine OSMR Fc Chimera binds with an EC50 of 0.02-0.04μg/ml.

    • Measured by its binding ability in a functional ELISA. When Recombinant Canine OSMR Fc Chimera is immobilized 2.5µg/mL (100µL/well), Recombinant Canine IL-31 His tag binds with an EC50 of 1.2-1.4μg/ml.

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