MIP-3α/CCL20 Protein, Human
CCL20,C-C motif chemokine 20,Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20,LARC,MIP3A,SCYA20,CCL-20,CKb4,Exodus,MIP-3a,ST38,chemokine (C-C motif) ligand 20,C-C motif chemokine ligand 20
货号： UA040084
- 价格： ￥810
- 规格：
- 数量：
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别名
CCL20,C-C motif chemokine 20,Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20,LARC,MIP3A,SCYA20,CCL-20,CKb4,Exodus,MIP-3a,ST38,chemokine (C-C motif) ligand 20,C-C motif chemokine ligand 20物种
Human抗原名称
MIP-3α/CCL20Accession
P78556表达序列
Ala27-Met96
表达宿主
E.coli分子量
8kDa
纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
No Tag性状
Lyophilized powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
1. Kwantwi LB, Wang S, Sheng Y, Wu Q. Multifaceted roles of CCL20 (C-C motif chemokine ligand 20): mechanisms and communication networks in breast cancer progression. Bioengineered. 2021 Dec;12(1):6923-6934.
2. Ikawa T, Miyagawa T, Fukui Y, Minatsuki S, Maki H, Inaba T, Hatano M, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y. Association of serum CCL20 levels with pulmonary vascular involvement and primary biliary cholangitis in patients with systemic sclerosis. Int J Rheum Dis. 2021 May;24(5):711-718.
Macrophage Inflammatory Protein-3 (MIP-3α), also known as chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC), is the only chemokine ligand for C-C motif chemokine ligand-receptor 6(CCR6), and is a member of the CC family and the alpha subfamily chemokines. Structurally, CCL20 contains four exons and three introns at their junctions which differ from other members of the CC chemokines. Chemokines are well known to play essential roles in the recruitment of immune cells and the development of lymphoid tissues. They also regulate the recruitment and trafficking of leucocytes during homeostasis and inflammation. Inflammatory chemokines are released to induce leukocyte infiltration to inflammatory site. Beyond these physiological roles, emerging studies have highlighted the indispensable role of chemokines and their receptors in tumor progression. It has become evident that chemokines regulate several oncogenic processes, including host immune response, tumor growth, angiogenesis, metastasis and chemoresistance.
电泳JSON
1μg (R: reducing condition, N: non-reducing condition).
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