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产品中心 细胞因子 生长因子

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FGF-1/FGF-Acidic Protein, Human

Fibroblast Growth Factor 1,FGF-1,Acidic Fibroblast Growth Factor,aFGF,Endothelial Cell Growth Factor,ECGFHeparin-Binding Growth Factor 1,HBGF-1,FGF1,FGFA

价格 ￥450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040032
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      Fibroblast Growth Factor 1,FGF-1,Acidic Fibroblast Growth Factor,aFGF,Endothelial Cell Growth Factor,ECGFHeparin-Binding Growth Factor 1,HBGF-1,FGF1,FGFA

    • Accession

      P05230-1

    • 表达序列

      Phe16-Asp155

    • 表达宿主

      E.coli

    • 分子量

      17kDa (Reducing)

    • 纯度

      ＞95% by SDS-PAGE & HPLC

    • 标记

      Unconjugated

    • 标签

      No Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      20mM PB, 150mM NaCl, 1mM DTT, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Human fibroblast growth factor 1 (FGF-1), also known as acidic fibroblast growth factor (FGF-Acidic), is one of the best characterized members of the FGF superfamily. FGF-1 is a powerful mitogen that exhibit potent effects on numerous different types of cells. It plays a number of roles in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer. FGF-1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF-1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Ligation triggers receptor dimerization, transphosphorylation, and internalization of receptor/FGF complexes.

    • 生物活性

      • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells, the EC50 for this effect is less than 0.5ng/ml.

    • 电泳

      • 2μg (R: reducing condition, N: non-reducing condition).

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