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产品中心 药物靶点和Fc受体 药物靶点

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Glycoprotein/GP RBD Fc Chimera Protein, Ebola virus

Glycoprotein/GP-RBD Protein (EBOV)

价格 ￥1,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA030094
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Ebola virus

  • 分子别名

    Glycoprotein/GP-RBD Protein (EBOV)

  • Accession

    AHX24649

  • 表达序列

    Met1-Phe308 with hFc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    72-95kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Hood CL, et al. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar;84(6):2972-82.
    2.Lee JE, et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10;454(7201):177-82.

背景介绍

  • The fourth gene of the Ebola virus (EBOV) encodes the glycoprotein GP, a multidomain and multifunctional class I fusion protein. It exists as trimers on the viral surface and mediates viral entry through a heterodimer of GP1 and GP2 subunits generated by furin cleavage. GP1 facilitates infection via its receptor-binding domain (RBD), which interacts with key host receptors such as TIM-1 and NPC1, while its mucin-like domain—modified by glycosylation—enhances infectivity and shields neutralization epitopes. GP2 drives membrane fusion and nucleocapsid release. Additionally, GP exhibits significant immunomodulatory functions: it downregulates integrin expression to disrupt vascular integrity, activates monocytes/macrophages via the TLR4 pathway triggering a cytokine storm, counteracts the antiviral effects of BST2, and acts as a decoy to evade antibody neutralization. These mechanisms collectively promote immune evasion and contribute to viral pathogenesis.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of Glycoprotein-GP RBD Fc Chimera Protein, Ebola virus is more than 80% determined by SEC-HPLC.

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