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产品中心 药物靶点和Fc受体 药物靶点

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MIS RII Llama IgG2b Fc Chimera Protein, Human

MRII,AMHR2,AMHR,MISR2,MIS type II receptor,MISRII

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011293
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    MRII,AMHR2,AMHR,MISR2,MIS type II receptor,MISRII

  • Accession

    Q16671-1

  • 表达序列

    Pro18-Ser144 with Llama IgG2b Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    55-72kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 标记

    Unconjugated

  • 标签

    Llama IgG2b Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Tanaka S, Mori M, Mafune K, Ohno S, Sugimachi K. A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. Br J Cancer. 2000 May;82(9):1557-60.
    2.Mohri Y, Shimizu M, Fujimoto T, Nishikawa Y, Ikeda A, Matsuda Y, Wada T, Kawaguchi C. A young child with pediatric multisystem inflammatory syndrome successfully treated with high-dose immunoglobulin therapy. IDCases.

背景介绍

  • The Anti-Müllerian Hormone Type II Receptor (AMHRII/MISRII) is a single-transmembrane serine/threonine kinase receptor within the TGF-beta superfamily that, upon binding its ligand, forms a complex with type I and type II kinases to initiate a phosphorylation-dependent signaling cascade. This pathway ultimately activates SMAD transcription factors and mediates Müllerian duct regression in male embryos. Mutations in this receptor cause Persistent Müllerian Duct Syndrome (PMDS), a disorder in genetic males characterized by the development of female reproductive tract structures, though the specific mechanism of AMHR2 gene activation remains incompletely understood. The recombinant human AMHR2/MISRII protein produced in HEK293 cells with a C-terminal Llama Fc tag is used for research purposes.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

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