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物种
Human分子别名
CD340, ERBB2, NEU, NGL, MLN19, TKR1Accession
P04626-1表达序列
Thr23-Thr652 with Human IgG1 Fc & Avi Tag at C-Terminus
表达宿主
HEK293分子量
60-80kDa (Reducing)纯度
> 95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Biotin标签
Human IgG1 Fc, Avi Tag性状
Lyophilized Powder缓冲体系
PBS, PH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Antonio C. Wolff; M. Elizabeth H. Hammond; JaredN. Schwartz; Karen L. Hagerty; D. Craig Allred; Richard J. Cote; MitchellDowsett; Patrick L. Fitzgibbons; Wedad M. Hanna; Amy Langer; Lisa M. McShane;Soonmyung Paik; Mark D. Pegram; Edith A. Perez; Michael F. Press; AnthonyRhodes; Catharine Sturgeon; Sheila E. Taube; Raymond Tubbs; Gail H. Vance; Marcvan de Vijver; Thomas M. Wheeler; Daniel F. Hayes: American Society of ClinicalOncology/College of American Pathologists Guideline Recommendations for HumanEpidermal Growth Factor Receptor 2 Testing in Breast Cancer, Arch Pathol Lab Med (2007) 131 (1): 18–43.
Human Epidermal Growth Factor Receptor 2 (HER2), also known as ERBB2, HER-2, HER-2/neu, NEU, NGL, TKR1, and c-erbB-2, is a protein associated with increased aggressiveness in breast cancers. HER2 is a member of the ErbB protein family, also known as the epidermal growth factor receptor family. It is a cell membrane-bound receptor tyrosine kinase that plays a role in signal transduction pathways leading to cell growth and differentiation.
The human ErbB2 protein consists of 1255 amino acids, including a 22 amino acid signal sequence, a 630 amino acid extracellular domain (ECD), a 23 amino acid transmembrane region, and a 580 amino acid cytoplasmic domain. HER2 is involved in development, cancer progression, communication at the neuromuscular junction, and the regulation of cell growth and differentiation. Phosphoinositide 3-kinase has been implicated in ErbB2 signal transduction, and the cytoplasmic domain of ErbB2 has been shown to interact with beta-catenin and plakoglobin.
电泳(SDS-PAGE)
1μg (R: reducing condition).
ELISA
Immobilized Anti-HER2 Monoclonal Antibody (Trastuzumab) (Cat. No. UA011035) at 2.0μg/mL (100μL/well) can bind Biotinylated ErbB2/Her2 Fc&Avi Tag Protein, Human (Cat. No. UA011015) with EC50 of 10.71-23.01 ng/mL.
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