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产品中心 ELISA试剂盒 OneStep ELISA 试剂盒

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Monkey TL1A/TNFSF15 OneStep ELISA Kit

价格 ￥3,000.00 （ 供应商现货 ： 3-5个工作日）
货号 S0C3145
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产品介绍

产品介绍 评论(0)

产品规格

  • 抗原名称

    TL1A/TNFSF15

  • 免疫原

    Recombinant Protein

  • 抗体类型

    Recombinant mAb

  • 反应种属 ?

    Mk

  • 纯化方式

    Protein A

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8'C as supplied.

试剂盒参数

    • Precision

      Intra-assay: 2.0%；
      Inter-assay: 3.5%

    • Sample type

      Cell culture supernatant; Serum; Plasma

    • Assay type

      Sandwich (quantitative)

    • Sensitivity

      1.757 pg/mL

    • Range

      7.81 pg/mL – 500 pg/mL

    • Recovery

      Cell culture supernatant: 113%
      Serum: 87%
      Plasma: 94%

    • Assay time

      60 minutes

    • Species reactivity

      Mk

    • CROSS REACTIVITY

      Hu
背景介绍

  • Monkey TL1A, also known as TNFSF15, is a protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on the surface of vascular endothelial cells and certain immune cells. This protein functions as a ligand for the death domain receptor 3 (DR3) on lymphocytes. Upon binding, it activates downstream signaling pathways such as NF-κB and MAPK, which promote inflammatory responses. Its primary role is involved in modulating immune functions, including T cell activation and proliferation. Research indicates that TL1A is a key player in the pathogenesis of various chronic inflammatory and autoimmune diseases, particularly those related to vascular inflammation. Consequently, it has been identified as a potential therapeutic target, with monoclonal antibodies against TL1A currently under investigation for treating conditions like inflammatory bowel disease and rheumatoid arthritis.

  • ELISA

    • Standard curve
      Example of Monkey TL1A/TNFSF15 standard curve in Assay Diluent DA4.

    • Linearity
      The concentrations of Monkey TL1A/TNFSF15 were measured and interpolated from the target standard curves and corrected for sample dilution.
      Sample is undiluted samples are as follows: Monkey serum was 2-fold dilution (50%). The interpolated dilution factor corrected values are plotted. The mean target concentration was determined to be 83.56 pg/mL in monkey serum.
      Sample is undiluted samples are as follows: Monkey plasma was 2-fold dilution (50%). The interpolated dilution factor corrected values are plotted. The mean target concentration was determined to be 71.88 pg/mL in monkey plasma.

    • To assess the linearity of the assay, sample were spiked with high concentrations of Monkey TL1A/TNFSF15 in various matrices and diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.

    • To assess the linearity of the assay, two samples were spiked with high concentrations of Monkey TL1A/TNFSF15 in various matrices and diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.

    • Protocol Diagram

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