Mouse Anti-Human CD163 Antibody (GHI/61)

CD163 is a cysteine-rich scavenger receptor (a member of the SRCR-SF family) encoded by the CD163 gene, primarily expressed on the surface of monocytes and macrophages, with a molecular weight of approximately 130 kDa. Its structure consists of an extracellular domain with nine SRCR domains, a transmembrane segment, and a cytoplasmic tail. CD163 specifically recognizes the hemoglobin-haptoglobin complex (Hb-Hp) and free hemoglobin (FHb), playing a crucial role in hemoglobin clearance and iron metabolism. CD163 exhibits significant immunomodulatory functions by suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and promoting anti-inflammatory factors (e.g., IL-10), thereby mitigating inflammatory responses. It also exerts antioxidant effects through pathways such as HO-1 activation during oxidative stress. The soluble form (sCD163), generated by ectodomain shedding, is elevated in conditions like cirrhosis, diabetes, and rheumatoid arthritis, making it a potential biomarker for inflammatory diseases. Additionally, CD163 serves as the key receptor for porcine reproductive and respiratory syndrome virus (PRRSV), highlighting its importance in veterinary research and disease-resistant breeding strategies.