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宿主来源
Mouse抗原名称
CD161分子别名
Killer cell lectin-like receptor subfamily B member 1A; NKR-P1A; Antigen 3.2.3; CD161 antigen-like family member A; Natural killer cell surface protein P1-3.2.3 (NKR-P1 3.2.3); CD161a; Nkrp1a; Klrb1a细胞定位
MembraneAccession
P27471克隆号
S-R628抗体类型
Mouse mAb抗体同种型
IgG1,k应用
FCM反应种属 ?
Rt阳性样本
SD Rat splenocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:2000 | Rt |
CD161, also known as KLRB1 or NKRP1A, is a C-type lectin-like receptor primarily expressed on the surface of natural killer (NK) cells and a subset of T cells, including mucosal-associated invariant T (MAIT) cells and some CD8+ T cells. It is particularly enriched in immune cells located in mucosal sites such as the gut and liver. CD161 binds to its ligand, lectin-like transcript 1 (LLT1, also known as CLEC2D), and this interaction can have both inhibitory and costimulatory effects on immune cells. In the context of cancer immunotherapy, CD161 has been identified as a potential inhibitory receptor in glioma-infiltrating T cells. Its activation by CLEC2D on tumor or immunosuppressive cells can dampen T cell responses against cancer cells. Recent studies suggest that blocking the CD161-CLEC2D interaction may enhance T cell-mediated antitumor activity, making CD161 a promising target for cancer immunotherapy.
流式分析
Flow cytometric analysis of SD Rat splenocytes labelling Rat CD161 antibody at 1/2000 (0.1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 605™ Antibody separately.
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