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宿主来源
Mouse抗原名称
Mouse CD64分子别名
High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI (FcRI); Fcgr1; Fcg1细胞定位
Cell membraneAccession
P26151克隆号
S-R614抗体类型
Mouse mAb抗体同种型
IgG1,k应用
FCM反应种属 ?
Ms纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
CD64, also known as FcγRI, is a high-affinity receptor for the Fc fragment of IgG and belongs to the immunoglobulin superfamily. It is primarily expressed on the surface of monocytes, macrophages, dendritic cells, and neutrophils. Under normal conditions, CD64 expression on neutrophils is low, but it rapidly increases within 4-6 hours upon stimulation by bacterial lipopolysaccharides (LPS), cytokines, or other inflammatory mediators. This upregulation makes CD64 a valuable biomarker for diagnosing bacterial infections, sepsis, and other inflammatory conditions. It has higher sensitivity and specificity compared to traditional markers like white blood cell count, C-reactive protein (CRP), and procalcitonin (PCT) for distinguishing bacterial infections from viral infections or non-infectious inflammation. Additionally, CD64 can be used to monitor treatment efficacy, predict postoperative infections, and guide antibiotic therapy.
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