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Cytokeratin 18 (M65) Recombinant Rabbit mAb (SDT-614-19)

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货号 S0B3658
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产品介绍

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产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Cytokeratin 18 (M65)

  • 免疫原

    Recombinant Protein

  • Accession

    P05783

  • 克隆号

    SDT-614-19

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 交叉反应

    Recognize both CK18 M30 fragment and full length CK18

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 纯度

    >95% by SEC-HPLC

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt, 2 to 8 °C as supplied

  • 应用

    Sandwich ELISA
背景介绍

  • Cytokeratin 18 (CK18) is a cytoskeletal protein and the main intermediate filament family member expressed in the liver and other epithelial tissues. The CK18 full-length form is released from necrotic cells, whereas a caspase-cleaved fragment is a product of the structural changes that occur during apoptosis. Soluble total and fragments of CK18 can be detected in human serum with enzyme-linked immunoassay (ELISA). The M65 assay measures total CK18, i.e., full-length and caspase-cleaved fragments of CK18 generated during cell necrosis and apoptosis, while the M30 assay detects a neoepitope created in the caspase-3 cleaved 30kDa fragment during cell apoptosis

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