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Rabbit抗原名称
MICB分子别名
MHC class I polypeptide-related sequence B; MIC-B;免疫原
Recombinant ProteinAccession
Q29980-1克隆号
SDT-1472-102抗体类型
Recombinant mAb抗体同种型
IgG应用
Sandwich ELISA反应种属 ?
Hu交叉反应
No cross-reactivity against MICB, NKG2D
纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt, 2 to 8 °C as supplied
MHC I polypeptide-related sequence B (MICB) is a highly glycosylated transmembrane protein encoded by the MICB gene, located on chromosome 6p21.33. It functions as a ligand for the NKG2D receptor, a type II receptor expressed on natural killer (NK) cells, CD8+ T cells, and γδ T cells. The binding of MICB to NKG2D activates cytolytic responses in these immune cells, promoting the elimination of stressed or infected cells. Unlike MHC class I molecules, MICB does not associate with β-2-microglobulin or bind peptides. MICB is stress-induced, meaning its expression increases under cellular stress conditions, such as DNA damage or viral infection. This protein is widely expressed in various tissues, including lymph nodes and bone marrow, highlighting its role in immune surveillance. The external domains of MICB are proteolytically cleaved by surface proteases and shed into the extracellular space. MICB shedding by cancer cells causes effective escape from NKG2D recognition and allows the development of cancers. Patients frequently have increased concentrations of soluble MICA/B molecules shed in the blood plasmas and sera, thus indicating that MICA/B shedding is a therapeutic target in immune-oncology.
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