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MICB Recombinant Rabbit mAb (SDT-1472-102)

货号: S0B3370

Datasheet COA
  • 价格: ¥1,355
  • 规格:
  • 数量:
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产品介绍 引用文献(0) 评论(0)

产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    MICB
  • 分子别名

    MHC class I polypeptide-related sequence B; MIC-B;
  • 免疫原

    Recombinant Protein
  • Accession

    Q29980-1
  • 克隆号

    SDT-1472-102
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 应用

    Sandwich ELISA
  • 反应种属 ?

    Hu
  • 交叉反应

    No cross-reactivity against MICB, NKG2D

  • 纯化方式

    Protein A
  • 浓度

    2 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt, 2 to 8 °C as supplied

  • 稀释度

    [{"application": "ELISA", "dilution": "", "species": ""}, {"application": "Sandwich ELISA", "dilution": "", "species": ""}, {"application": "CLIA", "dilution": "", "species": ""}, {"application": "Lateral Flow", "dilution": "", "species": ""}, {"application": "Dot Blot", "dilution": "", "species": ""}, {"application": "WB", "dilution": "", "species": ""}, {"application": "IP", "dilution": "", "species": ""}, {"application": "IHC-P", "dilution": "", "species": ""}, {"application": "ICC", "dilution": "", "species": ""}, {"application": "IF", "dilution": "", "species": ""}, {"application": "ICFCM", "dilution": "", "species": ""}, {"application": "FCM", "dilution": "", "species": ""}, {"application": "mIHC", "dilution": "", "species": ""}]
背景介绍
  • MHC I polypeptide-related sequence B (MICB) is a highly glycosylated transmembrane protein encoded by the MICB gene, located on chromosome 6p21.33. It functions as a ligand for the NKG2D receptor, a type II receptor expressed on natural killer (NK) cells, CD8+ T cells, and γδ T cells. The binding of MICB to NKG2D activates cytolytic responses in these immune cells, promoting the elimination of stressed or infected cells. Unlike MHC class I molecules, MICB does not associate with β-2-microglobulin or bind peptides. MICB is stress-induced, meaning its expression increases under cellular stress conditions, such as DNA damage or viral infection. This protein is widely expressed in various tissues, including lymph nodes and bone marrow, highlighting its role in immune surveillance. The external domains of MICB are proteolytically cleaved by surface proteases and shed into the extracellular space. MICB shedding by cancer cells causes effective escape from NKG2D recognition and allows the development of cancers. Patients frequently have increased concentrations of soluble MICA/B molecules shed in the blood plasmas and sera, thus indicating that MICA/B shedding is a therapeutic target in immune-oncology.

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