Osteocalcin/OST Recombinant Rabbit mAb (SDT-253-35)

Product Introduction

• Host

  Rabbit

• Antigen

  Osteocalcin/OST

• Synonyms

  OC, Bone Gla protein (BGP)

• Immunogen

  Synthetic Peptide

• Accession

  P02818

• Clone Number

  SDT-253-35

• Antibody Type

  Recombinant mAb

• Application

  Sandwich ELISA

• Reactivity

  Hu

• Purification

  Protein A

• Concentration

  2 mg/ml

• Conjugation

  Unconjugated

• Physical Appearance

  Liquid

• Storage Buffer

  PBS pH7.4, 0.03% Proclin 300

• Stability & Storage

  12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

• • Sandwich ELISA

    N/A

• Osteocalcin (OC), also known as bone gla protein (BGP), is a 49 amino acid vitamin K-dependent calcium binding protein with a molecular weight of 5.9 kDa. Carboxylated OC (Gla-OC), which is capable of binding calcium, is the active form of the protein and decarboxylated OC represents the inactive form. Gla-OC has three γ-carboxylated glutamic acid residues (Gla) at positions 17, 21, and 24 that are known to mediate strong binding to hydroxyapatite. OC synthesis is dependent on both vitamins D and K. Vitamin D directly induces OC synthesis and vitamin K stimulates the gamma-carboxylation of glutamic acid residues. During osteoclastic resorption, binding of undercarboxylated osteocalcin (Glu-OC) to bone decreases, resulting in an increase in Glu-OC level in blood and urine. P. D. Delmas and colleagues have shown that undercarboxylated OC is significantly increased in elderly women, suggesting an age-dependent impairment of OC γ-carboxylation. The presence of undercarboxylated OC in serum has also been associated with changes to the bone matrix and increased fragility.

• Paired Recommendations

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