申请试用 Human folate receptor alpha Recombinant Rabbit mAb (SDT-719-684)
Folate receptor alpha,FR-alpha,Adult folate-binding protein (FBP),Folate receptor 1,Folate receptor,adult,KB cells FBP,Ovarian tumor-associated antigen MOv18,FOLR,FOLR1
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宿主来源
Rabbit抗原名称
Human folate receptor alpha分子别名
Folate receptor alpha; FR-alpha; Adult folate-binding protein (FBP); Folate receptor 1; Folate receptor; adult; KB cells FBP; Ovarian tumor-associated antigen MOv18; FOLR; FOLR1免疫原
Synthetic Peptide细胞定位
Cell membrane, Secreted, EndosomeAccession
P15328克隆号
SDT-719-684抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?稀释度
应用 稀释度 推荐种属 IHC-P 1:100-1:250 Hu
Human folate receptor alpha (FOLR1) is a glycoprotein that plays a crucial role in the transport of folate, an essential vitamin, into cells. This receptor is highly expressed in certain tissues and is particularly notable for its involvement in various physiological processes including embryonic development and cellular proliferation. Its overexpression has been observed in numerous cancers, such as ovarian, lung, and breast cancer, making it a potential target for cancer diagnosis and targeted therapy. By binding to folate or folate analogs, FOLR1 facilitates the internalization of these molecules via endocytosis, thereby providing cells with the necessary folate for metabolic functions like DNA synthesis and repair.
免疫组化
IHC shows positive staining in paraffin-embedded human kidney. Anti-Human folate receptor alpha antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded human tonsil. Anti-Human folate receptor alpha antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human ovarian cancer (case 1). Anti-Human folate receptor alpha antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human ovarian cancer (case 2). Anti-Human folate receptor alpha antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of Human folate receptor alpha in tumor tissue.
Expression of Human folate receptor alpha in human tissue.
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