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Mouse抗原名称
HLA-DR分子别名
HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA-DRA1细胞定位
Cell membraneAccession
P01903克隆号
S-R566抗体类型
Mouse mAb抗体同种型
IgG2a应用
FCM反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
50 μg/ml标记
APC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Hu |
HLA-DR is a class II Major Histocompatibility Complex (MHC) antigen in human. It is primarily expressed on immune cells, especially dendritic cells and macrophages, and plays a crucial role in recognizing and distinguishing foreign substances from self-tissues. It is involved in regulating the activation status of these cells and plays a key role in immune responses, including anti-infection immunity, tumor immunity, and transplantation immunity. In organ transplantation, HLA-DR is closely related to organ transplant rejection reactions. In the fields of hematopoietic stem cell transplantation and bone marrow transplantation, HLA-DR also plays an important role. Changes in the expression level of HLA-DR are related to the diagnosis of inflammatory diseases, the assessment of severity, and the monitoring of immune status. Unlike other cell activation markers such as CD69, CD25, and CD38, HLA-DR is not expressed on most T cells and is only expressed on a subset of activated T cells during the late stages of an immune response.
流式分析
Multiparameter flow cytometric analysis of Human HLA-DR expression on human peripheral blood mononuclear cell populations. Human peripheral blood mononuclear cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 antibody and either APC Mouse IgG2a Isotype Control (Left panel) or SDT APC Mouse Anti-Human HLA-DR Antibody (Right panel) at 0.25 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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