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宿主来源
Rat抗原名称
Ly6G分子别名
Lymphocyte antigen 6G; Ly-6G; Ly-6G.1细胞定位
Cell membraneAccession
P35461克隆号
S-R481抗体类型
Rat mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse bone marrow纯化方式
Protein G浓度
0.1mg/ml标记
Alexa Fluor® 700性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Ms |
Ly6G, or lymphocyte antigen 6 complex locus G6D, is a cell surface marker predominantly expressed on neutrophils and granulocytes in mice. It is a GPI-anchored protein that plays a role in cell signaling and cell adhesion, and is often used as a marker for these particular cell populations. The expression of Ly6G directly correlates with the level of differentiation and maturation of these cells. In the context of immune cell research, Ly6G is often used alongside Ly6C, another cell surface marker that, together with Ly6G, helps distinguish between different granulocyte subsets. The Ly6G protein can also be targeted for therapeutic purposes. The depletion of Ly6G+ cells has been shown to affect tumor growth in certain cancer models, suggesting that neutrophils may have a role in promoting tumor progression in some contexts.
流式分析
- Flow cytometric analysis of Mouse Ly6G expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow were stained with Brilliant Violet 510™ Rat Anti-Mouse CD11b antibody and either Alexa Fluor® 700 Rat IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 700 Rat Anti-Mouse Ly6G antibody (Right panel) at 0.5 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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