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宿主来源
Rabbit抗原名称
Von Willebrand Factor分子别名
vWF, F8VWF免疫原
Synthetic Peptide细胞定位
SecretedAccession
P04275克隆号
S-663-120抗体类型
Recombinant mAb抗体同种型
IgG应用
IHC-P反应种属 ?
Hu纯化方式
Protein A浓度
1 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| IHC-P | 1:200 |
Von Willebrand Factor (VWF) is a large multimeric plasma glycoprotein primarily produced by endothelial cells and megakaryocytes. It is found in subendothelial matrices, plasma, and platelets. VWF is synthesized in endothelial cells in the form of Weibel-Palade bodies and in platelets, it is stored in the α-granules. VWF promotes the adhesion and aggregation of platelets at sites of vascular injury, which is a crucial step in the hemostatic process. VWF also serves as a molecular chaperone for coagulation factor VIII, transporting it to sites of injury, stabilizing its heterodimeric structure, and protecting it from premature clearance from the plasma. Furthermore, VWF forms molecular bridges between subendothelial collagen matrices and platelet surface receptor complexes GPIb-IX-V, further facilitating platelet adhesion to sites of vascular injury.
免疫组化
IHC shows positive staining in paraffin-embedded human colon. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human cardiac muscle. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human skeletal muscle. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human hemangioma of liver. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human bladder cancer. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human cervical squamous cell carcinoma. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung carcinoma. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
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